Epivir

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AIDS virusEpivir belongs to a class of anti-HIV drugs called Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs). For a description of the life-cycle of the AIDS virus, and the targets of each class of drugs, click here.

Epivir is marketed by ViiV Healthcare.

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Epivir (lamivudine, 3TC)

Pronunciation(s): Pronunciation: la-MI-vue-deen



What is lamivudine?
  • Lamivudine is an HIV medication. It is in a category of HIV medications called nucleoside reverse transcriptase inhibitors (NRTIs). Lamivudine prevents HIV from altering the genetic material of healthy CD4 cells. This prevents the cells from producing new virus and decreases the amount of virus in the body.
     
  • Lamivudine was approved for the treatment of HIV by the U.S. Food and Drug Administration (FDA) in 1995. Epivir, the brand name version of lamivudine, is sold in the U.S. by ViiV Healthcare. Generic lamivudine is sold in the U.S. by various manufacturers.
     
  • Epivir and generic lamivudine are available in pharmacies as a single drug. Epivir is also available in combination tablets, notably Epzicom (Ziagen and Epivir) and Combivir (Retrovir [zidovudine] and Epivir). A generic combination tablet containing lamivudine plus zidovudine is also available.
     
  • Lamivudine is also approved for the treatment of chronic hepatitis B infection (Epivir HBV). The lamivudine dose normally used to treat hepatitis B is one 100mg tablet once a day. The dose used to treat HIV is one 300mg tablet once a day, or one 150mg tablet every 12 hours. If you are infected with both HIV and hepatitis B, it is important that you take the dose used to treat HIV.
     
  • Lamivudine must be used in combination with other HIV drugs.
     
  • A patient assistance program (PAP) has been established for people living with HIV who do not have private or public health insurance and are unable to afford brand-name Epivir. To learn more about the PAP for Epivir, call 888-825-5249 or refer to the program's website for more information. For those with private health insurance, a program has been established to help cover each Epivir co-payment, up to $100 every month. To learn more about this co-pay program, check out mysupportcard.com.

What is known about lamivudine?
  • The recommended dose for lamivudine is one 300mg tablet once a day, or one 150mg tablet every 12 hours.
     
  • For children, both a liquid formula and a scored tablet of lamivudine are available. Infants and children receiving the liquid formulation should be given 4 mg per kilogram of body weight. Dosing with the tablet depends on the weight of the child, and their ability to swallow pills. For children between 14 and 21 kilograms (31 and 47 pounds), a half tablet (75mg) should be taken twice a day for a total daily dose of 150mg. For children between 22 and 29 kilograms (48 and 65 pounds), a half tablet should be taken in the morning (75mg) and a full tablet (150mg) should be taken at night, for a total daily dose of 225mg. Children 30 kilograms (66 pounds) and over should take a full tablet (150mg) twice a day for a total daily dose of 300mg.
     
  • The chemical structure of lamivudine looks very much like that of Emtriva (emtricitabine).
     
  • Lamivudine won't likely be effective for people who have already taken and become resistant to Emtriva. This is because one of the key changes, or mutations, in HIV's genetic structure that occurs as a result of Emtriva therapy also causes resistance to Epivir.
     
  • Lamivudine (and Combivir, Trizivir, Epzicom and generic zidovudine/lamivudine tablets) can be taken with food or on an empty stomach. Many patients report less stomach discomfort if these medications are taken with food. To learn about treatment options for children, click here.
     
  • Numerous studies have demonstrated that lamivudine is effective for the treatment of HIV when combined with other HIV drugs, including another NRTI and at least one protease inhibitor, non-nucleoside reverse transcriptase inhibitor (NNRTI), or integrase inhibitor.
     
  • For HIV-positive adults beginning HIV drug therapy for the first time, lamivudine can be used as a component of recommended drug combinations established by the United States Department of Health and Human Services in its treatment guidelines. To learn more about these recommendations and options, click here.
     
  • Therapy with lamivudine can cause certain changes (mutations) in HIV's structure to occur. Some mutations will prevent lamivudine from working against HIV. The key mutation that causes resistance to lamivudine (the M184V mutation in HIV's reverse transcriptase gene) can cause the virus to be at least partially resistant to other NRTIs, including abacavir and will likely prevent the NRTI Emtriva from working at all against the virus. However, lamivudine resistance might make the virus even more sensitive to other NRTIs, including Viread (tenofovir).

What about Epivir for hepatitis B?
  • Epivir is sold as "Epivir HBV" for the treatment of chronic hepatitis B infection in people who are not also infected with HIV.
     
  • The dose of Epivir HBV used to treat chronic hepatitis B is one 100mg every day. However, this dose is much lower than the one used to treat HIV. Thus, if you have both HIV and chronic hepatitis B, your doctor should prescribe the dose used to treat HIV (300mg once a day). This dose is high enough to help treat both infections.
     
  • The hepatitis B virus (HBV) does not become resistant to Epivir as quickly as HIV. In turn, even if your HIV is resistant to Epivir, it might still be useful to continue taking this drug if you are also trying to treat hepatitis B.
     
  • If you have hepatitis B and HIV and plan to stop taking Epivir, your doctor might want to frequently check your liver enzymes after stopping treatment. This is because HBV can "flare" after Epivir treatment is stopped, which can cause damage to the liver.

What about drug interactions?
  • TMP/SMX (Bactrim; Septra), a treatment used to prevent Pneumocystis pneumonia (PCP), can increase the amount of lamivudine in the body. However, it is not necessary to change the doses of either TMP/SMX or lamivudine.
     
  • Lamivudine should not be taken at the same time as Emtriva or Truvada (containing Viread and Emtriva). This is because lamivudine and Emtriva are very similar and it is not believed that combining these two HIV drugs will make a regimen any more effective against the virus. Similarly, lamivudine should not be taken with other drugs that contain lamivudine, such as Combivir of Epzicom.
     
  • Other drug interactions might be possible. However, it is believed that lamivudine can be safely taken at the same time as most drugs used to treat HIV and AIDS-related complications.

What about side effects?
  • Lactic acidosis, which can be fatal, and severe liver problems (fatty liver) have been reported in people taking nucleoside reverse transcriptase inhibitors (NRTIs). These problems are more likely to occur in HIV-positive people taking drug regimens that contain Zerit or Zerit and Videx (ddI). It is possible that abacavir can also cause these side effects. Contact your doctor immediately if you experience nausea, vomiting, or unusual or unexpected stomach discomfort; weakness and tiredness; shortness of breath; weakness in the arms and legs; yellowing of the skin or eyes; or pain in the upper stomach area. These may be early symptoms of lactic acidosis or liver problems.
     
  • Rarely, lamivudine can cause inflammation of the pancreas (pancreatitis). Pancreatitis is a rare but serious side effect that can be life-threatening in some cases. Notify your doctor immediately if you develop symptoms of pancreatitis, including nausea, vomiting, diarrhea, and abdominal pain.
     
  • Another rare side effect of lamivudine is peripheral neuropathy, which can result in pain, tingling, numbness, or burning in the hands and/or feet. Stopping Epivir and starting another NRTI that does not usually cause peripheral neuropathy—for example, zidovudine or abacavir—is often the best way to stop peripheral neuropathy.
     
  • Other, less serious side effects may occur. Continue taking lamivudine and talk to your doctor if you experience a cough, dizziness, fatigue, stomach discomfort, headache, and trouble sleeping. Epivir has also been known to cause anemia (decreased red blood cell function), hair loss, rash, and neutropenia (decreased neutrophils, a type of white blood cell)
     
  • HIV drug regimens containing NRTIs, including lamivudine, can cause increased fat levels (cholesterol and triglycerides) in the blood, abnormal body-shape changes (lipodystrophy; including increased fat around the abdomen, breasts, and back of the neck, as well as decreased fat in the face, arms, and legs), and diabetes. These side effects of HIV drug therapy are reviewed in our lessons on Lipodystrophy, Facial Lipoatrophy, and Risks To Your Heart (Hyperlipidemia).
     
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.


Can pregnant women take lamivudine?

  • Lamivudine is classified by the FDA as a pregnancy category C drug. Pregnancy category C means that animal studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. HIV-positive women who become pregnant should discuss the benefits and possible side effects of HIV treatment to help protect their babies from HIV (see our lesson called Family Planning, Pregnancy & HIV).
     
  • It is not known whether lamivudine passes into breast milk and what effect it may have on a nursing baby. To prevent transmission of the virus to uninfected babies, it is recommended that HIV-positive mothers not breast-feed.

Who should not take lamivudine?

  • Before taking this medication, tell your doctor if you have: kidney disease; liver disease; a history of pancreatitis; low red blood cells or neutrophils. You may not be able to take lamivudine, or you may require lower doses or special monitoring during treatment, if you have any of these conditions.
     
  • Be sure to tell your doctor if you have allergies to medications, including lamivudine.

Where can I learn more about clinical trials that are using Epivir?
  • If you would like to find out if you are eligible for any clinical trials that include lamivudine, visit ClinicalTrials.gov, a site run by the U.S. National Institutes of Health. The site has information about all HIV-related clinical studies in the United States. For more info, you can call their toll-free number at 1-800-HIV-0440 (1-800-448-0440) or email contactus@aidsinfo.nih.gov.

Last Revised: May 04, 2014

This content is written by the POZ and AIDSmeds editorial team. For more information, please visit our "About Us" page.


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