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Once HIV's genetic material is inside the cell's nucleus, it directs the cell to produce new HIV.
The strands of viral DNA in the nucleus separate, and special enzymes create a complementary strand of genetic material called messenger RNA or mRNA (instructions for making new HIV).
Transcription can be blocked by antisense antivirals or transcription inhibitors (TIs), new classes of drugs that are in the earliest stage of research. | 
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