A Smart + Strong Site
Subscribe to:
Newsletters
POZ magazine
JOIN AIDSMEDS YouTube

Back to home » Treatment News » Top Stories

Most Popular Stories
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
FDA Approves New Single-Tablet HIV Regimen, Triumeq
Life Expectancy for Young People With HIV Is Nearly Normal
A 15-Year Jump in Life Expectancy for People With HIV
Scientists Devise Method of Snipping HIV From Immune Cells
Monkey HIV Vaccine Success Opens Door for Human Trials
HIV Combo Pill Less Toxic Thanks to New Form of Tenofovir
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Shingles
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


emailprint

August 15, 2012

Compounds in Green Tea, Chocolate, Red Wine Show Promise for HIV Neuro Problems

by Tim Horn

A group of plant polyphenols known as catechins—found in green tea, dark chocolate and red wine—may help prevent the neurological complications more common among people living with HIV, according to a paper published online by the Journal of NeuroVirology and summarized by the publisher in a news announcement.

Under the direction of Joseph Steiner, MD, of the Johns Hopkins University department of neurology in Baltimore, the authors found that catechins—notably epicatechin and epigallocatechin gallate (EGCG)—can induce the production of a protein called brain-derived neurotrophic factor (BDNF) that neurons need in order to function correctly.

Ongoing research, including work conducted at Georgetown University Medical Center that was reported last month in the Journal of Neuroscience, confirms that people living with HIV may be more susceptible to neurocognitive impairment and depression because they have lower levels of BDNF in their brains compared with those not living with the virus.

These findings have paved the way for a number of therapeutic possibilities. One is the study of compounds that can induce the production of BDNF in the brain.

Steiner and his colleagues began by analyzing the effects of roughly 2,000 compounds—including organic substances and U.S. Food and Drug Administration–approved drugs—on neurons in the laboratory. Nine of the tested compounds were related to epicatechin, which is found in cocoa tree seeds and green tea leaves. Further screening and comparison with resveratrol, the antioxidant found in red wine, identified epicatechin and EGCG as being the most effective at helping protect neurons by inducing production of BDNF.

Although the antioxidant activities of epicatechin and EGCG are well documented, the Journal of NeuroVirology publisher notes in its news announcement, “the discovery that they could be responsible for inducing production of BDNF is an exciting advancement in this area. The fact that these compounds readily cross the blood-brain barrier further increases their therapeutic potential, as this is often a major stumbling block in the development of therapies directed at the brain. This provides hope for patients with HIV as there is currently no neuroprotective therapy available for patients with HIV-associated cognitive impairment.”

Steiner and his colleagues conclude: “Due to its simpler structure and more efficient blood-brain barrier penetration properties, epicatechin might be the best therapeutic candidate for neurodegenerative diseases. These include HIV-associated cognitive disorders where oxidative stress is an important pathophysiological mechanism.”

They add that more research is required to explore just how well these naturally occurring compounds can prevent and reverse neurocognitive problems in people living with HIV.

Search: polyphenols, catechins, green tea, chocolate, wine, epicatechin, egcg, steiner, johns hopkins, neurocognitive, brain, hand, hiv, cognitive


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (3 total)


[Go to top]

Quick Links
About HIV and AIDS
The Cure
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Disclosure
Lipodystrophy
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Blogs
Conference Coverage
Health Services Directory
POZ Magazine
AIDSmeds on Twitter


Conference Coverage

XX International AIDS Conference
(AIDS 2014)
Melbourne, Australia
July 20 - 25, 2014


21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014


7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013


more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.