A Smart + Strong Site
Subscribe to:
E-newsletters
POZ magazine
JOIN AIDSMEDS YouTube

Back to home » Treatment News » Top Stories

Most Popular Stories
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
A 15-Year Jump in Life Expectancy for People With HIV
Life Expectancy for Young People With HIV Is Nearly Normal
Failure to Awaken Dormant Cells Deals Blow to HIV Cure Research
Scientists Devise Method of Snipping HIV From Immune Cells
Media Cooks Up Claim That Soy Sauce Treats, Even Cures HIV
FDA Approves New Single-Tablet HIV Regimen, Triumeq
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Shingles
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


emailprint

September 12, 2008

People Now Able to Stay on First Antiretroviral Regimens Longer

People living with HIV are now able to remain on a first antiretroviral (ARV) regimen—which now usually includes once daily dosing and fewer pills—for much longer than people taking older twice-daily, multiple pill regimens, according to the authors of a study published in the October 1 issue of AIDS.

The majority of studies on first ARV regimen durability—the average length of time that a person’s first ARV regimen continues to keep virus undetectable without needing to change medications for side effects or tolerability reasons—were conducted in the late 1990s using older medications that often needed to be taken two or more times per day and involved taking many pills. These studies suggested that people remained on these older ARV regimens without changes for efficacy, tolerability or safety, for about 1.6 years in real world settings. James Willig, MD, of the Infectious Diseases Unit at the University of Alabama in Birmingham (UAB), and his colleagues, however, reasoned that most ARV regimens are now much more convenient, tolerable and potent than older regimens and therefore likely have greater durability.

Dr. Willig’s team studied the medical records of 542 patients enrolled in the UAB HIV clinic. They separated the patients into two groups, including 309 patients who’d started their first ARV regimen on or before July 31, 2004, and were more likely to be taken older combinations of drugs, and 233 who’d started ARV after July 2004, who were more likely to be taking newer combinations of drugs. The majority of the patients in both groups were male, and 56 percent were black. Nearly half had a history of mental illness, and many had a history of substance abuse.

Overall, Willig’s team found that patients who started older regimens were significantly more likely to discontinue treatment due to side effects than people who started newer regimens. The duration of the first regimen was also nearly a year shorter, on average, in those on older regimens than newer regimens. In fact, the average length of time using a first regimen containing Videx (didanosine) or Zerit (stavudine) without switching for drug failure, side effects or tolerability was only 401 days, whereas the average regimen duration in those who started a regimen containing abacavir (found in Ziagen, Epzicom and Trizivir) or tenofovir (found in Viread, Truvada and Atripla) was 1,253 days.

When Willig’s team conducted further analysis they found that once-daily dosing and the use of non-nucleoside reverse transcriptase inhibitors (NNRTIs) were the factors associated with the greatest duration. The authors recommend that further studies be conducted to determine whether these factors are consistently associated with better regimen duration.

Search: treatment durability, tenofovir, Viread, Truvada, Atripla, abacavir, Ziagen, Epzicom, Trizivir, James Willig, University of Alabama, Birmingham, UAB


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (0 total)


[Go to top]

Quick Links
AIDSmeds en Español
About HIV and AIDS
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Disclosure
Lipodystrophy
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Blogs
Conference Coverage
Health Services Directory
POZ Magazine


    guycmh328
    Columbus
    Ohio


    Newhopenate
    New Hope
    Pennsylvania


    ernienyc
    Bronx
    New York


    clintonjrsyr
    syracuse
    New York
Click here to join POZ Personals!
Conference Coverage

XX International AIDS Conference
(AIDS 2014)
Melbourne, Australia
July 20 - 25, 2014


21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014


7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013


more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.