A Smart + Strong Site
Subscribe to:
E-newsletters
POZ magazine
JOIN AIDSMEDS YouTube

Back to home » Treatment News » Top Stories

Most Popular Stories
An Almost Normal Life Expectancy for People With HIV?
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
A 15-Year Jump in Life Expectancy for People With HIV
Misleading News Reports Suggest HIV Cure Is Near
New HIV Drug Class Shows Promise
Gene Therapy Shows Promise in Controlling HIV
Potential Microbicide Tricks HIV Into Sudden Death
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Shingles
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


emailprint

October 1, 2013

Newly Found HIV Replication Pathway May Lead to New Drugs

The discovery of a new HIV replication route may eventually lead to advancements in antiretroviral (ARV) therapy and attempts to eradicate the virus. Publishing their findings in the Journal of Virology, researchers investigated the phenomenon that more than 90 percent of HIV fails to integrate its DNA into human cells, leaving unintegrated viral DNA in the cell. (Integration is a key component of the HIV lifecycle; integrase inhibitors attack the virus at this juncture.) In the past, researchers have assumed that these stranded viruses could not copy themselves.

But as the scientists discovered, some of this unintegrated virus is able to skip the integration process and still reproduce itself, producing new viruses that can in turn infect other cells.
 
“Although this is not the virus’s main method for replicating, having this option available can help HIV survive,” the study’s lead researcher, David N. Levy, PhD, associate professor of basic science and craniofacial biology at the New York University College of Dentistry, said in a release. “These new findings suggest one mechanism by which HIV may be surviving in the face of antiviral drugs, and suggests new avenues for research into eliminating infection.”

Levy’s team also discovered that these unintegrated viruses can survive in human cells for weeks, providing themselves a kind of cover against ARVs and other natural immune responses.

To read the NYU release, click here.

To read the journal abstract, click here.

Search: HIV, antiretrovirals, Journal of Virology, unintegrated viral DNA, New York University College of Dentistry, David N. Levy.


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (0 total)


[Go to top]

Quick Links
AIDSmeds en Español
About HIV and AIDS
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Disclosure
Lipodystrophy
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Blogs
Conference Coverage
Health Services Directory
POZ Magazine


    fokisi
    Long Beach
    California


    soy_Ric
    Rochester
    New York


    latinpozdallas
    Dallas
    Texas


    jap022964
    el dorado
    Arkansas
Click here to join POZ Personals!
Conference Coverage

21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014


7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013


20th Conference on Retroviruses and Opportunistic Infections
(CROI 2013)
Atlanta, GA
March 3 - 7, 2013


more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.